The I-Know project joins leading European Stroke experts in developing advanced models of the progression of brain damage immediately after acute stroke. The understanding of ischemic brain damage – and hence the development of efficient therapies to treat this devastating disease – is limited by our ability to integrate clinical and multimodal neuroimaging data into operational models of tissue damage in the hours and days following sudden reductions of blood flow to crucial brain regions.

Based on a large database of patient imaging data, genetic profile and clinical/biochemical findings retrieved from Electronic Health Records, the project has developed sophisticated models to simulate the progression of brain damage.

Two main features of the technology:

·         With the embedded knowledge of leading experts and hundreds of previous stroke cases, the simulation model provides automated image analysis and expert diagnostic support across infrastructural boundaries, supporting acute treatment of acute stroke to all EU-citizens.

·         With the statistical power of modern informatics and neuroimaging techniques, the technology allows the detection of efficacy signals in small patient cohorts, supporting the cost-effective development of new therapies.

Read more about the I-Know project at this website.

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